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KMID : 0043319950180020118
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Archives of Pharmacal Research
1995 Volume.18 No. 2 p.118 ~ p.120
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Hydrolysable Tannins and Related Compound having Cytotoxic Activity from the Fruits of Terminalia chebula
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Lee Seung-Ho
Ryu Shi-Yong
Choi Sang-Un
Lee Chong-Ock
No Zae-Sung
Kim Seong-Ki
Ahn Jong-Woong
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Abstract
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The cytotoxicity-directed fractionation of MeOH extract of Terminalia chebula fruits led to the isolation of three hydrolyzed tannins and a related compound, gallic acid(1), ,. chebulagic acid (III) and chebulinic acid(IV), as active principles. They were shoen to exhibit moderate cytotoxicity against cultured human tumor cell lines including A-549, SK-OV-3, Sk-MEL-2, XF-498 and HCT-15 in vitro.
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KEYWORD
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Terminalia chebula, Gallic acid, Chebulagic acid, chebulinic acid, Cytotoxicity, Antitumor
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